How is acne caused by rosacea treated with ivermectin?

How is acne caused by rosacea treated with ivermectin?
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What is ivermectin used for?

Avermectin is a medication that belongs to the avermectins class. They are often used to treat parasitic diseases such as bug and worm infestations. It is offered for sale as a 1% strength skin cream under the Soolantra brand.

How does it function?

Ivermectin is recommended as a first-line treatment by dermatologists, the Primary Care Dermatology Society (PCDS), and the National Institute of Health and Care Excellence (NICE).

It is unknown what particularly causes rosacea acne. However, those who experience it seem to have immune system abnormalities that result in an overabundance of inflammatory mediators, which are cell signaling molecules that control the immune response.

Furthermore, the skin of people with rosacea seems to contain a larger proportion of Demodex mites.  In 35–50% of rosacea patients, the locations of facial skin lesions are linked to elevated demodex mite counts. The mites irritate the skin when they penetrate hair follicles and sebaceous glands. They damage the skin’s outermost layer, the epithelium. They also cause the skin to become extremely sensitive. Additionally, those with rosacea are more susceptible to UV radiation. The end result is the formation of pustules and papules.

Acne rosacea is associated with increased transepidermal water loss and compromised skin barrier function.

Ivermectin diffuses into the pilosebaceous units and kills the Demodex mites.

How well does it function?

It was discovered through two double-blind, randomised controlled studies that ivermectin 1% cream applied once day was more beneficial than a placebo. 38.4% and 40.1%, respectively, of each research study reported success as “clear” or “almost clear,” compared to 11.6% and 18.8% of those who took a placebo.

The cream was used once a day for 52 weeks. In one experiment, for example, the improvement assessed as “clear” or “almost clear” increased from 38.4% at week 12 to 71.1% at week 52.

Further studies show that receiving ivermectin 1% cream rather than metronidazole gel enhanced patients’ quality of life more.

Negative effects

In clinical trials, the most common side effect—which happened to less than 1% of patients—was burning or stinging of the skin. The skin may be a little dry, itchy, or inflamed.

How should one apply 1% ivermectin cream?

Pat the skin dry after washing. Apply a pea-sized amount to each of the five primary facial features: the forehead, nose, two cheeks, and chin. Apply the lotion to your skin in even, thin layers. Take care to avoid getting any in your mouth, nose, or eyes. Allow the cream to naturally dry on your face before applying makeup, sunscreen, or further rosacea treatments.  Wash your hands gently after using.

During the first week of treatment, your rosacea may appear more severe. This is because the dead and dying status of the Doxycycline 100mg first caused an increase in skin sensitivity. But after this, things should gradually improve, so please continue. Although 1% ivermectin cream seldom exacerbates rosacea, there is a very small chance that your skin won’t be able to tolerate it in the long run.

The lotion contains alcohol; in particular, stearyl and cetyl alcohol have been linked to contact dermatitis. Additionally, localized contact dermatitis can be caused by propylene glycol, propyl parahydroxybenzoate (E216), and methyl parahydroxybenzoate (E218).

Who is the product meant for?

Pregnancy should not be treated with ivermectin 1% cream because not enough study has been done on the subject. Furthermore, if you are nursing, it is not encouraged.

Final thoughts

Rosacea is a skin condition that is extremely painful and difficult to treat. It is imperative that 1% ivermectin cream be included in the list of treatments. It has proven to be more successful than metronidazole gel. It’s a topical drug with few side effects and a high rate of tolerability.